Four people were killed, including a 71-year-old man, after a fire tore through an e-bike service store on the first floor of a building near Manhattan’s Chinatown neighborhood early Tuesday morning, according to the police.

The fire, at a six-story mix-use building at 80 Madison Street, started around 12:15 a.m. and spread through the store, which has residential apartments above it, according to officials.

Six adults were taken to three area hospitals, where four of them — two women and two men — died. Two women were in critical condition, the police said.

The fire left soot smeared above the broken-out windows of the building, which also houses a deli, a laundromat and a news stand. A mountain of charred e-bikes and scooters was piled up on the corner.

The cause of the fire was under investigation Tuesday morning, the New York Fire Department said.

The Red Cross said in a tweet that it was providing emergency shelter for eight households, comprising 23 adults and two children.

As e-bikes and scooters have become ubiquitous in the city since the pandemic, officials have grappled with the flammability of lithium-ion batteries and the risk they pose to New Yorkers. The batteries power devices like phones, laptops and power tools, as well as the electric vehicles that are widely used by delivery people and for general transport.

Lithium-ion batteries started about 200 fires in New York City last year.

In April, two siblings, a 7-year-old boy and his 19-year-old sister, were killed in an “explosion of fire” caused by an e-bike that was being charged near the front door of an apartment building in the Astoria neighborhood of Queens.

Chelsia Rose Marcius contributed reporting.

This is a breaking story and will be updated.